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Volume 31 , Issue 4
July/August 2011
Pages 355 (e9-e16)

Bone Regeneration with Self-Assembling Peptide Nanofiber Scaffolds in Tissue Engineering for Osseointegration of Dental Implants

Tomoyuki Kohgo, DDS/Yoichi Yamada, DDS, PhD/Kenji Ito, DDS, PhD/Akihiro Yajima, DDS, PhD/Ryoko Yoshimi, DDS/Kazuto Okabe, DDS/Shunsuke Baba, DDS, PhD/Minoru Ueda, DDS, PhD

PMID: 21837298
DOI: 10.11607/prd.00.0990

The aim of this study was to evaluate the correlation between the osseointegration of dental implants and tissue-engineered bone using a nanofiber scaffold, PuraMatrix (PM). The first molar and all premolars in the mandibular regions of dogs were extracted, and three bone defects were prepared with a trephine bur on both sides of the mandible after 4 weeks. The experimental groups were as follows: (1) PM, (2) PM and dog mesenchymal stem cells (dMSCs), (3) PM, dMSCs, and platelet-rich plasma, and (4) control (defect only). Implants were placed in the prepared areas 8 weeks later and were assessed by histologic and histomorphometric analyses (bone-to-implant contact [BIC]). The BICs for groups 1, 2, 3, and 4 were 40.77%, 50.35%, 55.64%, and 30.57%, respectively. The findings indicate that PM may be useful as a scaffold for bone regeneration around dental implants. (Int J Periodontics Restorative Dent 2011;31:e9–e16.)

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